Cardiovascular disease is the leading cause of death in many industrialized countries. Intensive effort has been made to understand the basic mechanisms. One field of investigation in recent years is the study of circadian rhythms. Increasing evidence has shown adverse effects of circadian disruption in the cardiovascular system. CRD Pharma CardioResync is the platform that is investigating time dependent effects for development improved drugs for cardiovascular diseases.
Day-night variations in blood pressure (BP) and heart rate (HR) are among the best known circadian rhythms of physiology. In humans, there is a 24-h variation in BP with a sharp rise before awakening, the highest BP value is around midmorning.
Many cardiovascular events, such as sudden cardiac death, myocardial infarction and stroke, display diurnal variations with an increased incidence in the morning.
These events, as well as kidney albuminuria and progression to end-stage renal diseases, are relatively common in patients whose blood pressure fails to decline during the night, so-called non-dippers. Inverse dippers—BP rises instead of decreases at night—showed even higher cardiovascular mortality.